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Haplotype Assembly Using Manifold Optimization and Error Correction Mechanism
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DOI：10.1109/LSP.2019.2910383.png)
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Abstract
En 中文
Recent matrix completion based methods have not been able to properly model the haplotype assembly problem for noisy observations. To deal with such cases, we propose a new minimum error correction (MEC) based matrix completion problem over the manifold of rank-one matrices. We then prove the convergence of a specific iterative algorithm to solve this problem. From the simulation results, the proposed method not only outperforms some well-known matrix completion based methods, but also shows a more accurate result compared to a most recent MEC-based algorithm for haplotype estimation.
Keywords:
Haplotype assembly
manifold optimization
matrix completion
minimum error correction
Hamming distance
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