.png){kind=icon}
.png){kind=icon}
Return
Harnessing structural instability for cell durotaxis
.png){kind=icon}
PRE
AI
DOI：10.1007/s10409-019-00853-2.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Cells were suggested to sense matrix rigidity by applying fluctuating forces, but the underlying mechanism remains elusive. Here, with a generic filament-crosslinker modeling system for stress fibers, we demonstrate that high mechanical forces can be induced by specific protein-protein interactions with biased kinetics. Strikingly, we further find that there exist two patterns of force generation, a stable pattern and a fluctuated pattern, in agreement with previous experimental observations. Our analysis indicates that the fluctuated force profile is essentially due to force-induced structural instability during structural assembly. We suggest that how cells utilize or circumvent such stable forces or fluctuated forces may be important in other biological processes as well, though whether such forces should be regarded as passive or active is still tentative.
Keywords:
Protein-protein interaction
Biased kinetics
Force generation
Stable pattern
Fluctuated pattern
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.