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Harnessing thermo-hydrogen coupling with palladium hydride nanoparticles for superior antitumor therapy
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DOI：10.1039/D6RA02688E.png)
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Abstract
En 中文
Photothermal nanomaterials have gained significant attention in cancer treatment due to their excellent photothermal conversion properties. However; photothermal therapy alone often results in incomplete tumor ablation. To improve therapeutic efficacy; we introduce a thermo-hydrogen coupled strategy using palladium hydride (PdH) nanoparticles that combine photothermal heating with hydrogen-driven oxidative stress modulation. PdH nanoparticles were synthesized via a chemical method and systematically characterized using transmission electron microscopy (TEM); X-ray diffraction (XRD); UV-Vis spectrophotometry; and thermos response measurements. The results demonstrated that PdH nanoparticles possess small size; high structural stability; good dispersibility; and a photothermal conversion efficiency of 61.9% at 100 µg mL−1. Hydrogen release upon 532 nm laser irradiation was confirmed using methylene blue decolorization. In vitro studies demonstrated that under laser irradiation; PdH nanoparticles efficiently and stably released hydrogen; enhancing intracellular oxidative stress and leading to selective apoptosis in liver cancer cells while sparing normal liver cells. This effect resulted in an 82% cancer cell death rate; significantly surpassing that of Pd nanoparticles without hydrogen. These findings highlight the mechanistic advantage of thermo-hydrogen synergy and support PdH nanoparticles as a promising platform for controlled and selective cancer therapy.
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