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Heme oxygenase-1/CO signaling suppresses NLRP3 inflammasome–mediated stromal fibrosis in primary myelofibrosis

delete2026-07-20
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OA
AI
L
Lucia Longhitano
E
Enrico La Spina
S
Sebastiano Giallongo
C
Cesarina Giallongo *
J
Jessica Ferrigno
L
Laura Orlando
V
Vittorio Del Fabro
R
Rosario Caltabiano
G
G. Conti
M
Michelino Di Rosa
G
Giuseppe Broggi
E
Elisabetta Pricoco
V
Vittorio Calabrese
A
Andrea Duminuco
G
Giuseppe Alberto Palumbo
G
Gabriella Marsala
G
Giovanni Li Volti
I
Ignazio Barbagallo
D
Daniele Tibullo
DOI：10.1016/j.freeradbiomed.2026.07.030delete
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Abstract

Abstract

En 中文
• HO-1 is markedly downregulated in primary myelofibrosis. • Activation of the HO-1/CO pathway suppresses tumor-induced NLRP3 signaling. • NLRP3 modulates HO-1 expression. • NLRP3/HO-1 axis contributes to myelofibrosis.
Keywords:
Heme oxygenase 1
Inflammasome NLRP3
Myelofibrosis
Fibrosis
Tumor microenvironment
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Free Radical Biology and Medicine cover
Free Radical Biology and Medicine
IF:
8.2
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2.1W
Citations:
5.4W

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University of Enna Kore
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67
Papers: 47
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A
azienda sanitaria provinciale catania
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2
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A
A.O.U. Policlinico G. Rodolico-San Marco
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25
Papers: 7
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university of catania
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