Hepatitis C Virus Replication

Keisuke Tabata

doi:10.1101/cshperspect.a037093

2019-09-30

Keisuke Tabata

Christopher J. Neufeldt

Ralf Bartenschlager *

DOI：10.1101/cshperspect.a037093

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摘要

En 中文

Replication and amplification of the viral genome is a key process for all viruses. For hepatitis C virus (HCV), a positive-strand RNA virus, amplification of the viral genome requires the synthesis of a negative-sense RNA template, which is in turn used for the production of new genomic RNA. This process is governed by numerous proteins, both host and viral, as well as distinct lipids and specific RNA elements within the positive- and negative-strand RNAs. Moreover, this process requires specific changes to host cell ultrastructure to create micro-environments conducive to viral replication. This review will focus on describing the processes and factors involved in facilitating or regulating HCV genome replication.

Keyword:

DEPENDENT RNA-POLYMERASE

NONSTRUCTURAL PROTEIN 5A

3' NONTRANSLATED REGION

DE-NOVO INITIATION

MEMBRANOUS REPLICATION

SECONDARY STRUCTURE

UNTRANSLATED REGION

HCV REPLICATION

BINDING PROTEIN

CODING REGION

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期刊

Cold Spring Harbor Perspectives in Medicine

IF:

10.1

论文数:

3.0K

被引数:

2.2W

机构

Ruprecht Karls University Heidelberg

学者数:

5.6W

论文数: 4.3W

被引数: 4.9W

引用论文

Template requirements and binding of hepatitis C virus NS5B polymerase during in vitro RNA synthesis from the 3′-end of virus minus-strand RNA

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IF3.8

2015-05-01

OAAI

Li, You; Yamane, Daisuke; Lemon, Stanley M.