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Hierarchical Geodesic Models in Diffeomorphisms

delete2015-08-26
delete23
PRE
AI
N
Nikhil Singh *
J
Jacob Hinkle
S
Sarang Joshi
P
P. Thomas Fletcher
DOI:10.1007/s11263-015-0849-2delete
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摘要

摘要

En 中文
Hierarchical linear models (HLMs) are a standard approach for analyzing data where individuals are measured repeatedly over time. However, such models are only applicable to longitudinal studies of Euclidean data. This paper develops the theory of hierarchical geodesic models (HGMs), which generalize HLMs to the manifold setting. Our proposed model quantifies longitudinal trends in shapes as a hierarchy of geodesics in the group of diffeomorphisms. First, individuallevel geodesics represent the trajectory of shape changes within individuals. Second, a grouplevel geodesic represents the average trajectory of shape changes for the population. Our proposed HGM is applicable to longitudinal data from unbalanced designs, i.e., varying numbers of timepoints for individuals, which is typical in medical studies. We derive the solution of HGMs on diffeomorphisms to estimate individuallevel geodesics, the group geodesic, and the residual diffeomorphisms. We also propose an efficient parallel algorithm that easily scales to solve HGMs on a large collection of 3D images of several individuals. Finally, we present an effective model selection procedure based on cross validation. We demonstrate the effectiveness of HGMs for longitudinal analysis of synthetically generated shapes and 3D MRI brain scans.
Keyword:
Longitudinal modeling
Diffeomorphisms
Mixed-effects modeling
LDDMM
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期刊

International Journal of Computer Vision 封面图
International Journal of Computer Vision
IF:
9.3
论文数:
3.9K
被引数:
2.8W

机构

U
university of north carolina
学者数:
7.4W
论文数: 6.5W
被引数: 93
U
University of North Carolina Chapel Hill
学者数:
3.9W
论文数: 3.1W
被引数: 46
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