High-density Lipoprotein Cholesterol: Function, Dysfunction, and Clinical Implications

doi:10.1016/j.ajpc.2026.101672

2026-05-14

Sophia Trabanino

Annabelle Rodríguez *

Fatima Rodriguez

DOI：10.1016/j.ajpc.2026.101672

原文链接

查看原文

摘要

En 中文

大型观察性研究显示高密度脂蛋白胆固醇（HDL-C）与心血管疾病（CVD）风险之间存在U型关联，挑战了HDL-C作为均一心脏保护因子的传统观点。在临床实践中，HDL-C升高常引发不确定性，难以判断患者是受到保护还是CVD风险增加。心肌梗死相关的孟德尔随机化研究不支持HDL-C升高具有基因组因果保护作用。相反，候选基因分析已识别出与HDL-C升高和CVD风险增加均相关的常见及稀有变异，进一步证实HDL-C作为异质性生物标志物而非治疗靶点的概念。

Keyword:

cholesterol

inflammation

atherosclerosis

coronary artery disease

immune checkpoint

genomics

AI总结

对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。

期刊

American Journal of Preventive Cardiology

IF:

5.9

论文数:

1.0K

被引数:

1.3K

机构

stanford university

学者数:

1.1W

论文数: 4.3K

被引数: 0

University of Connecticut

学者数:

2.4W

论文数: 2.2W

被引数: 2.5W

引用论文

Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease

Science

IF0

2016-03-11

OAAI

Paolo Zanoni; Sumeet A. Khetarpal; Daniel B. Larach; William F. Hancock-Cerutti; John S. Millar; Marina Cuchel; Stephanie DerOhannessian; Anatol Kontush; Praveen Surendran; Danish Saleheen; Stella Trompet; J. Wouter Jukema; Anton De Craen; Panos Deloukas; Naveed Sattar; Ian Ford; Chris Packard; Abdullah al Shafi Majumder; Dewan S. Alam; Emanuele Di Angelantonio; Goncalo Abecasis; Rajiv Chowdhury; Jeanette Erdmann; Børge G. Nordestgaard; Sune F. Nielsen; Anne Tybjærg-Hansen; Ruth Frikke Schmidt; Kari Kuulasmaa; Dajiang J. Liu; Markus Perola; Stefan Blankenberg; Veikko Salomaa; Satu Männistö; Philippe Amouyel; Dominique Arveiler; Jean Ferrieres; Martina Müller-Nurasyid; Marco Ferrario; Frank Kee; Cristen J. Willer; Nilesh Samani; Heribert Schunkert; Adam S. Butterworth; Joanna M. M. Howson; Gina M. Peloso; Nathan O. Stitziel; John Danesh; Sekar Kathiresan; Daniel J. Rader; Sarah Watson; Ellen M. Schmidt; Sebanti Sengupta; Stefan Gustafsson; Stavroula Kanoni; Andrea Ganna; Jin Chen; Martin L. Buchkovich; Samia Mora; Jacques S. Beckmann; Jennifer L. Bragg-Gresham; Hsing-Yi Chang; Ayşe Demirkan; Heleen M. Den Hertog; Ron Do; Louise A. Donnelly; Georg B. Ehret; Tõnu Esko; Mary F. Feitosa; Teresa Ferreira; Krista Fischer; Pierre Fontanillas; Ross M. Fraser; Daniel F. Freitag; Deepti Gurdasani; Kauko Heikkilä; Elina Hyppönen; Aaron Isaacs; Anne U. Jackson; Åsa Johansson; Toby Johnson; Marika Kaakinen; Johannes Kettunen; Marcus E. Kleber; Xiaohui Li; Jian’an Luan; Leo-Pekka Lyytikäinen; Patrik K. E. Magnusson; Massimo Mangino; Evelin Mihailov; May E. Montasser; Ilja M. Nolte; Jeffrey R. O’Connell; Cameron D. Palmer; Ann-Kristin Petersen; Serena Sanna; Richa Saxena; Susan K. Service; Sonia Shah; Dmitry Shungin; Carlo Sidore; Ci Song; Rona J. Strawbridge; Ida Surakka; Toshiko Tanaka; Tanya M. Teslovich; Gudmar Thorleifsson; Evita G. Van den Herik; Benjamin F. Voight; Kelly A. Volcik; Lindsay L. Waite; Andrew Wong; Ying Wu; Weihua Zhang; Devin Absher; Gershim Asiki; Inês Barroso; Latonya F. Been; Jennifer L. Bolton; Lori L. Bonnycastle; Paolo Brambilla; Mary S. Burnett; Giancarlo Cesana; Maria Dimitriou; Alex S. F. Doney; Angela Döring; Paul Elliott; Stephen E. Epstein; Gudmundur Ingi Eyjolfsson; Bruna Gigante; Mark O. Goodarzi; Harald Grallert; Martha L. Gravito; Christopher J. Groves; Göran Hallmans; Anna-Liisa Hartikainen; Caroline Hayward; Dena Hernandez; Andrew A. Hicks; Hilma Holm; Yi-Jen Hung; Thomas Illig; Michelle R. Jones; Pontiano Kaleebu; John J. P. Kastelein; Kay-Tee Khaw; Eric Kim; Norman Klopp; Pirjo Komulainen; Meena Kumari; Claudia Langenberg; Terho Lehtimäki; Shih-Yi Lin; Jaana Lindström; Ruth J. F. Loos; François Mach; Wendy L. McArdle; Christa Meisinger; Braxton D. Mitchell; Gabrielle Müller; Ramaiah Nagaraja; Narisu Narisu; Tuomo V. M. Nieminen; Rebecca N. Nsubuga; Isleifur Olafsson; Ken K. Ong; Aarno Palotie; Theodore Papamarkou; Cristina Pomilla; Anneli Pouta; Muredach P. Reilly; Paul M. Ridker; Fernando Rivadeneira; Igor Rudan; Aimo Ruokonen; Hubert Scharnagl; Janet Seeley; Kaisa Silander; Alena Stancáková; Kathleen Stirrups; Amy J. Swift; Laurence Tiret; Andre G. Uitterlinden; L. J. van Pelt; Sailaja Vedantam; Nicholas Wainwright; Cisca Wijmenga; Sarah H. Wild; Gonneke Willemsen; Tom Wilsgaard; James F. Wilson; Elizabeth H. Young; Jing Hua Zhao; Linda S. Adair; Dominique Arveiler; Themistocles L. Assimes; Stefania Bandinelli; Franklyn Bennett; Murielle Bochud; Bernhard O. Boehm; Dorret I. Boomsma; Ingrid B. Borecki; Stefan R. Bornstein; Pascal Bovet; Michel Burnier; Harry Campbell; Aravinda Chakravarti; John C. Chambers; Yii-Der Ida Chen; Francis S. Collins; Richard S. Cooper; George Dedoussis; Ulf de Faire; Alan B. Feranil; Luigi Ferrucci; Nelson B. Freimer; Christian Gieger; Leif C. Groop; Vilmundur Gudnason; Ulf Gyllensten; Anders Hamsten; Tamara B. Harris; Aroon Hingorani; Joel N. Hirschhorn; Albert Hofman; G. Kees Hovingh; Chao Agnes Hsiung; Steve E. Humphries; Steven C. Hunt; Kristian Hveem; Carlos Iribarren; Marjo-Riitta Järvelin; Antti Jula; Mika Kähönen; Jaakko Kaprio; Antero Kesäniemi; Mika Kivimaki; Jaspal S. Kooner; Peter J. Koudstaal; Ronald M. Krauss; Diana Kuh; Johanna Kuusisto; Kirsten O. Kyvik; Markku Laakso; Timo A. Lakka; Lars Lind; Cecilia M. Lindgren; Nicholas G. Martin; Winfried März; Mark I. McCarthy; Colin A. McKenzie; Pierre Meneton; Andres Metspalu; Leena Moilanen; Andrew D. Morris; Patricia B. Munroe; Inger Njølstad; Nancy L. Pedersen; Chris Power; Peter P. Pramstaller; Jackie F. Price; Bruce M. Psaty; Thomas Quertermous; Rainer Rauramaa; Veikko Salomaa; Dharambir K. Sanghera; Jouko Saramies; Peter E. H. Schwarz; Wayne H.-H. Sheu; Alan R. Shuldiner; Agneta Siegbahn; Tim D. Spector; Kari Stefansson; David P. Strachan; Bamidele O. Tayo; Elena Tremoli; Jaakko Tuomilehto; Matti Uusitupa; Cornelia M. van Duijn; Peter Vollenweider; Lars Wallentin; Nicholas J. Wareham; John B. Whitfield; Bruce H. R. Wolffenbuttel; Jose M. Ordovas; Eric Boerwinkle; Colin N. A. Palmer; Unnur Thorsteinsdottir; Daniel I. Chasman; Jerome I. Rotter; Paul W. Franks; Samuli Riatti; L. Adrienne Cupples; Manjinder S. Sandhu; Stephen S. Rich; Michael Boehnke; Panos Deloukas; Karen L. Mohlke; Erik Ingelsson; Dongfeng Gu; Robert Roberts; Hugh Watkins; Stefan Blankenberg; Robert Clarke; Rory Collins; Bong-Jo Kim; Ruth McPherson; Markku S. Nieminen; Christopher O'Donnell; Stefan Schreiber; Agneta Siegbahn; Pierre A. Zalloua

High-Density Lipoprotein Cholesterol, High-Sensitivity C-Reactive Protein, and Cardiovascular Disease in United States Adults

The American Journal of Cardiology

IF0

2012-11-01

PREAI

Kyle R. Bilhorn; Yanting Luo; Brian T. Lee; Nathan D. Wong

Development and Validation of the American Heart Association's PREVENT Equations 美国心脏协会预防方程的开发和验证

CIRCULATION

IF38.6

2024-02-06

PREAI

Khan, Sadiya S.; Matsushita, Kunihiro; Sang, Yingying; Ballew, Shoshana H.; Grams, Morgan E.; Surapaneni, Aditya; Blaha, Michael J.; Carson, April P.; Chang, Alexander R.; Ciemins, Elizabeth; Go, Alan S.; Gutierrez, Orlando M.; Hwang, Shih-Jen; Jassal, Simerjot K.; Kovesdy, Csaba P.; Lloyd-Jones, Donald M.; Shlipak, Michael G.; Palaniappan, Latha P.; Sperling, Laurence; Virani, Salim S.; Tuttle, Katherine; Neeland, Ian J.; Chow, Sheryl L.; Rangaswami, Janani; Pencina, Michael J.; Ndumele, Chiadi E.; Coresh, Josef

Scavenger receptor-BI is a receptor for lipoprotein(a)

JOURNAL OF LIPID RESEARCH

IF4.1

2013-09-01

OAAI

Yang, Xiao-Ping; Amar, Marcelo J.; Vaisman, Boris; Bocharov, Alexander V.; Vishnyakova, Tatyana G.; Freeman, Lita A.; Kurlander, Roger J.; Patterson, Amy P.; Becker, Lewis C.; Remaley, Alan T.

High-density lipoprotein modulates thrombosis by preventing von Willebrand factor self-association and subsequent platelet adhesion

Blood

IF0

2016-02-04

OAAI

Dominic W. Chung; Junmei Chen; Minhua Ling; Xiaoyun Fu; Teri Blevins; Scott Parsons; Jennie Le; Jeff Harris; Thomas R. Martin; Barbara A. Konkle; Ying Zheng; José A. López

New Roles of HDL in Inflammation and Hematopoiesis

ANNUAL REVIEW OF NUTRITION

IF0

2012-08-21

OAAI

Zhu, Xuewei; Parks, John S.

The plasma lecithin:cholesterol acyltransferase reaction

Journal of Lipid Research

IF0

1968-03-01

OAAI

John A. Glomset

HDL Measures, Particle Heterogeneity, Proposed Nomenclature, and Relation to Atherosclerotic Cardiovascular Events

CLINICAL CHEMISTRY

IF6.3

2011-03-01

447

PREAI

Rosenson, Robert S.; Brewer, H. Bryan, Jr.; Chapman, M. John; Fazio, Sergio; Hussain, M. Mahmood; Kontush, Anatol; Krauss, Ronald M.; Otvos, James D.; Remaley, Alan T.; Schaefer, Ernst J.

2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk (vol 41, pg 111, 2019)

EUROPEAN HEART JOURNAL

IF35.6

2019-11-14

OAAI

Mach, F.

Effect of Glucagon-like Peptide-1 Receptor Agonists on Lipid Profiles Among Type 2 Diabetes: A Systematic Review and Network Meta-analysis

CLINICAL THERAPEUTICS

IF3.6

2015-01-01

174

PREAI

Sun, Feng; Wu, Shanshan; Wang, Jing; Guo, Shuxia; Chai, Sanbao; Yang, Zhirong; Li, Lishi; Zhang, Yuan; Ji, Linong; Zhan, Siyan

查看更多内容