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High-density oligonucleotide arrays
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AI
DOI：10.1016/0956-5663(96)83302-1.png)
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摘要
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We are attempting to produce high-density arrays of surface-bound oligonucleotides for hybridization experiments. Our approach is to mechanically miniaturize conventional DNA synthesis chemistry. Ink-jet printer heads are used to deliver small drops of reagents to a chemically modified silicon dioxide surface, where they react to synthesize DNA. The drops are confined to small areas by a pattern of hydrophobic surface modifications, thus allowing the formation of high-density arrays without mixing between adjacent drops.
Keyword:
oligonucleotide arrays
DNA hybridization
ink-jet
surface tension
期刊
IF:
10.5
论文数:
1.8W
被引数:
7.7W
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