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High lipoprotein(a) results in overestimation of BQ-based low-density lipoprotein-cholesterol measurement
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DOI：10.1016/j.jlr.2026.101080.png)
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Abstract
En 中文
Most conventional low-density lipoprotein cholesterol (LDL-C) assays are standardized by the CDC reference procedure of beta-quantification (BQ) method, which involves density-based ultracentrifugation to separate very low-density lipoprotein (VLDL) and LDL. Apolipoprotein (apo) (a) covalently binds to apoB, altering lipoprotein density thereby affecting this separation. We evaluated the impact of lipoprotein(a) [Lp(a)] on LDL-C assay accuracy.
Keywords:
lipoprotein (a)
LDL
VLDL
cholesterol
lipoproteins
beta-quantification method
ultracentrifugation
gel permeation high performance liquid chromatography
apo
apolipoprotein
BQ
beta-quantification
GP-HPLC
gel permeation high performance liquid chromatography
Lp(a)
lipoprotein(a)
MnCl2
manganese(II) chloride
TG
triglyceride
WB
western blotting
TC
total cholesterol
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