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High-throughput impedance spectroscopy biosensor array chip
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DOI：10.1098/rsta.2013.0107.png)
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Impedance spectroscopy is a powerful tool for characterizing materials that exhibit a frequency dependent behaviour to an applied electric field. This paper introduces a fully integrated multi-channel impedance extraction circuit that can both generate AC stimulus signals over a broad frequency range and also measure and digitize the real and imaginary components of the impedance response. The circuit was fabricated in a 0.5 mu m complementary metal-oxide semiconductor. Tailored for cellular membrane interface characterization, the signal generator produces sinusoidal waves from 10 mHz to 10 kHz. To suit a variety of applications, the impedance extraction circuit provides a programmable current measurement range from 100 pA to 100 nA with a measured resolution of approximately 100 fA. Occupying only 0.045 mm(2) per measurement channel, the circuit is compact enough to include nearly 200 channels in a 3 x 3 mm(2) die area.
Keyword:
complementary metal-oxide semiconductor
impedance spectroscopy
biosensor array
frequency synthesizer
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