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Hippocampal pattern separation supports reinforcement learning

delete2019-03-06
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Ian C. Ballard *
A
Anthony D. Wagner
S
Samuel M. McClure
DOI:10.1038/s41467-019-08998-1delete
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摘要

摘要

En 中文
Animals rely on learned associations to make decisions. Associations can be based on relationships between object features (e.g., the three leaflets of poison ivy leaves) and outcomes (e.g., rash). More often, outcomes are linked to multidimensional states (e.g., poison ivy is green in summer but red in spring). Feature-based reinforcement learning fails when the values of individual features depend on the other features present. One solution is to assign value to multi-featural conjunctive representations. Here, we test if the hippocampus forms separable conjunctive representations that enables the learning of response contingencies for stimuli of the form: AB+, B-, AC-, C+. Pattern analyses on functional MRI data show the hippocampus forms conjunctive representations that are dissociable from feature components and that these representations, along with those of cortex, influence striatal prediction errors. Our results establish a novel role for hippocampal pattern separation and conjunctive representation in reinforcement learning.
Keyword:
ORBITOFRONTAL CORTEX
PREFRONTAL CORTEX
NUCLEUS-ACCUMBENS
MEMORY
REPRESENTATION
PREDICTION
SYSTEMS
ASSOCIATION
MECHANISMS
STRIATUM
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期刊

Nature Communications 封面图
Nature Communications
IF:
15.7
论文数:
9.4W
被引数:
91.2W

机构

U
University of California Berkeley
学者数:
3.5W
论文数: 2.8W
被引数: 11.3W
S
Stanford University
学者数:
9.6W
论文数: 8.2W
被引数: 17.0W
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