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Hippocampal remodeling in chronic pain: Structural, functional, cellular, metabolic, and molecular mechanisms and therapeutic perspectives

delete2026-07-28
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OA
AI
Y
Yanan Zhang
X
Xiangxin Xing
W
Wenyu Chen
X
Xinyu Zheng
X
Xintong Yu
X
Xuqiang Wei
C
Chenchen Feng
L
Linxi Sun
Z
Zifan Liu
D
Deheng Wang *
K
Ke Wang *
DOI：10.1016/j.phrs.2026.108358delete
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Abstract

Abstract

En 中文
• Chronic pain drives multiscale remodeling of the hippocampus. • Structural and connectivity alterations occur in the hippocampus. • Metabolic dysregulation contributes to hippocampal dysfunction. • Neuronal and glial alterations are linked to pain comorbidities. • Multiple molecular mechanisms underlie hippocampal remodeling.
Keywords:
Chronic pain
Hippocampus
Synaptic plasticity
Neuroinflammation
Neurotrophic signaling
Neuron-glia interaction
Circuit dysfunction

Journal

Pharmacological Research cover
Pharmacological Research
IF:
10.5
Papers:
8.7K
Citations:
3.6W

Organization

S
shandong university
Scholars:
9.1W
Papers: 6.3W
Citations: 94
S
shanghai university of traditional chinese medicine
Scholars:
1.6W
Papers: 7.7K
Citations: 15
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