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Histone Deacetylase 7 protects against pathologic cardiac hypertrophy
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DOI：10.1016/j.yjmcc.2026.06.001.png)
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Abstract
En 中文
• HDAC7 overexpression protects against hypertrophy in vitro and in vivo. • HDAC7 interacts with and represses MEF2D to suppress hypertrophic gene expression. • Our findings demonstrate the therapeutic potential of HDAC7 as anti-hypertrophic agent.
Keywords:
HDAC7
MEF2D
Cardiac hypertrophy
Angiotensin II
Transverse aortic constriction
HDAC
histone deacetylase
MEF2
myocyte enhancer factor 2
OE
overexpression
CM
cardiomyocyte
SIRT
Sirtuin
NLS
Nuclear localization signal
NES
Nuclear export signal
hiPSC-CMs
Human induced pluripotent stem cell derived CMs
NMCMs
Neonatal mouse cardiomyocytes
Ang II
Angiotensin II
KEGG
Kyoto Encyclopedia of genes and Genomes
TAC
transverse aortic constriction
LVIDd
Left ventricular internal diameters at end diastole
LVIDs
Left ventricular internal diameters at end systole
KEGG
Kyoto Encyclopedia of Genes and Genomes
AAVs:
Adeno associated viruses
PGC-1α
PPARγ coactivator 1α
PGC-1β
PPARγ coactivator 1β
HK2
Hexokinase2
ACS
Acyl-CoA synthetase
ACADL
Long-chain acyl-CoA dehydrogenase
ATPsβ
ATP synthase-β
GLYPM
Glycogen phosphorylase
CPT1
Carnitine palmitoyl transferase
MCAD
medium chain acyl-CoA dehydrogenase
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