HMMER web server: 2026 update

Aleksandar Rajković

doi:10.1093/nar/gkag373

2026-04-27

DOI：10.1093/nar/gkag373

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摘要

En 中文

HMMER网络服务器，可访问地址为https://www.ebi.ac.uk/Tools/hmmer，提供在线访问HMMER软件套件（http://hmmer.org/）中用于蛋白质分析的隐马模型工具。用户可以对多种定期更新的蛋白质序列数据库进行序列相似性搜索，或使用蛋白质家族数据库中的隐马模型库对蛋白质序列进行结构域和家族注释。自2018年更新以来，序列数据库的持续指数级增长需要大幅改进基础设施，以保持搜索性能速度和服务可靠性。为此，网络界面已使用现代网络技术（JavaScript和React）完全重新设计，为用户提供增强的体验，包括基于会话的搜索历史和简化的结果可视化。网络应用程序编程接口已重写，以更好地支持通过更新端点和基于JSON的响应进行程序化访问。基础设施已重新设计，通过水平扩展和异步作业处理，能够高效处理对更大数据库的搜索。目标数据库选项已更新，以反映当前使用模式和数据可用性。HMMER网络服务器对所有用户免费开放，无需登录。

Keyword:

HMMER

web server

profile hidden Markov models

protein sequence analysis

database search

期刊

Nucleic Acids Research

IF:

13.1

论文数:

3.6W

被引数:

29.0W

机构

Harvard University

学者数:

26.5W

论文数: 22.0W

被引数: 28.7W

European Bioinformatics Institute and Wellcome Trust Genome Campus

学者数:

论文数: 2

被引数: 0

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