How proteins fold

Carlos Bustamante

doi:10.1038/s41580-026-00993-x

2026-07-02

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DOI：10.1038/s41580-026-00993-x

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尽管蛋白质结构现在可以准确预测，但蛋白质如何折叠仍悬而未决。单分子实验与先进计算工具的融合将有助于阐明折叠路径，并确定折叠是通过能量漏斗、离散折叠单元（foldons）还是两者兼有而进行。这一解析将定义蛋白质折叠和错误折叠的基本机制。尽管蛋白质结构预测取得了进展，但蛋白质如何折叠仍不明确。理解蛋白质（错误）折叠将需要单分子技术和先进的计算工具。

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Nature Reviews Molecular Cell Biology

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90.2

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Utrecht University

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