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How to perform a meta-analysis with R: a practical tutorial

delete2019-09-28
delete3.2K
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Sara Balduzzi *
G
Gerta Rücker
G
Guido Schwarzer
DOI:10.1136/ebmental-2019-300117delete
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摘要

摘要

En 中文
Objective Meta-analysis is of fundamental importance to obtain an unbiased assessment of the available evidence. In general, the use of meta-analysis has been increasing over the last three decades with mental health as a major research topic. It is then essential to well understand its methodology and interpret its results. In this publication, we describe how to perform a meta-analysis with the freely available statistical software environment R, using a working example taken from the field of mental health. Methods R package meta is used to conduct standard meta-analysis. Sensitivity analyses for missing binary outcome data and potential selection bias are conducted with R package metasens. All essential R commands are provided and clearly described to conduct and report analyses. Results The working example considers a binary outcome: we show how to conduct a fixed effect and random effects meta-analysis and subgroup analysis, produce a forest and funnel plot and to test and adjust for funnel plot asymmetry. All these steps work similar for other outcome types. Conclusions R represents a powerful and flexible tool to conduct meta-analyses. This publication gives a brief glimpse into the topic and provides directions to more advanced meta-analysis methods available in R.
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期刊

Evidence-Based Mental Health 封面图
Evidence-Based Mental Health
IF:
11.4
论文数:
269
被引数:
2.7K

机构

U
University of Freiburg
学者数:
3.3W
论文数: 2.4W
被引数: 3.4W
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