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Huangqi Guizhi Wuwu decoction alleviate Oxaliplatin-Induced Peripheral Neuropathy by adjusting the myelin regeneration
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DOI：10.1016/j.phymed.2025.157039.png)
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Abstract
En 中文
• We target the changes in myelin sheath during the development of OIPN and conduct microscopic studies on it. • We conduct systematic research on “phospholipid metabolism- inflammatory microenvironment- myelin regeneration”. • We explore the mechanism of the compound by integrating network pharmacology, metabolomics, and lipidomics. • The results reveal that regulating myelin regeneration may provide ideas for future prevention and treatment of OIPN.
Keywords:
Oxaliplatin-induced peripheral neurotoxicity
Huangqi Guizhi Wuwu decoction
Myelin regeneration
Metabolomics
Network pharmacology
Lipidomics
Journal
IF:
8.3
Papers:
9.0K
Citations:
3.1W
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