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摘要
En 中文
The importance of B cells and their critical role in the maintenance of health through generation of antibody-mediated immune protection is undoubted. However, the differences between the responses of B cells with different surface phenotypes in different microanatomical sites as well as diversity in B-cell function outside antibody production are just starting to be acknowledged and resolved. This series of reviews and papers that focus on human B cells will be divided across two issues. The first part of the review series in this issue captures practical information on identifying B-cell subtypes in blood in health and inflammatory diseases as well as describing aspects of B-cell diversity depending on immunoglobulin isotype and microanatomical context. It also explores our current understanding of cytokine production by human B cells and the effect of obesity on the B-cell response. The last review in this issue will reflect on the important lessons learned from the SARS-CoV-2 pandemic; in particular the role of antigen availability and its effect on B-cell memory and antibody production.
Keyword:
B cells
antibodies
inflammatory diseases
cytokines
期刊
C
IF:
3.8
论文数:
6.3K
被引数:
1.4W
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引用论文
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B cells and tertiary lymphoid structures as determinants of tumour immune contexture and clinical outcomeB细胞和三级淋巴样结构是肿瘤免疫环境和临床结果的决定因素.png)
PREAI
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收藏B-1 Cell Heterogeneity and the Regulation of Natural and Antigen-induced IgM ProductionB-1细胞异质性以及天然和抗原诱导的IgM产生的调控
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