logo
科言猫学术研究的AI总结
language
手机端手机端
  • Phone Feature微信小程序
简体中文简体中文
notice消息通知
博客博客
delete
arrow
返回

HuNT: A Reference Transcriptome Atlas for Human Normal Tissues

delete2026-05-18
delete0
delete
OA
AI
唐凯临 封面图
唐凯临 (Kailin Tang) *
X
XinYan Xu
X
Xinyue Tang
X
XinWen Wu
Z
ZiHao Li
J
Jian Gao
S
ShiYue Zhang
S
SaiFeng Mo
Z
Zikun Chen
M
Mou Zhang
H
Hao Ding
Y
Yao Shi
Y
YiHeng Wang
Y
YiXin Chen
陈默涵 封面图
陈默涵 (Mohan Chen)
曹志伟 封面图
曹志伟 (Zhiwei Cao) *
DOI：10.1007/s43657-025-00250-9delete
delete原文链接
delete分享
delete收藏
查看原文
摘要

摘要

En 中文
随着转录组学技术的快速发展，正常人类组织的基因表达谱已被频繁用作研究衰老和疾病机制的有价值参考。尽管已建立个体数据库，但大多数人类组织仍采样不足。同时，由于固有的分布偏差，RNA-seq和微阵列平台的表达谱必须分别分析，进一步削弱了健康样本的统计效力。本研究构建了包含29,769个样本、覆盖74种人类正常组织类型或部位的全面人类正常组织转录组图谱（HuNT），其样本量和组织多样性分别比知名GTEx数据库大70%和37%。更重要的是，该图谱实现了对RNA-seq和微阵列表达谱按组织类型整合分析，而非单独计算。基于迄今为止最大的人类样本集，HuNT提供了最新信息：（1）组织特异性基因；（2）各组织的稳定且高表达的管家基因；（3）全人类组织的基因表达全景；（4）指定组织中查询基因的相关性最高的基因。文中还展示了4个公认生物标志物的案例研究。随着未来数据积累，HuNT不仅可用于提供人类正常组织的基因表达全景，还可作为推导潜在标志基因乃至治疗靶点的基准。HuNT目前可通过http://hunt.badd-cao.net/免费访问。
Keyword:
Transcriptome atlas
Human normal tissues
Integrated transcriptome
Tissue-specific genes
Housekeeping genes
AI总结

AI总结

对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。

期刊

P
Phenomics
IF:
6.2
论文数:
306
被引数:
710

机构

L
life sciences and technology
学者数:
69
论文数: 26
被引数: 0
S
School of Life Sciences
学者数:
3.9K
论文数: 1.2K
被引数: 9
引用论文

引用论文

The Bgee suite: integrated curated expression atlas and comparative transcriptomics in animals
errNUCLEIC ACIDS RESEARCH
IF13.1
err2020-10-10
err102
errOAAI
errBastian, Frederic B.; Roux, Julien; Niknejad, Anne; Comte, Aurelie; Costa, Sara S. Fonseca; de Farias, Tarcisio Mendes; Moretti, Sebastien; Parmentier, Gilles; de Laval, Valentine Rech; Rosikiewicz, Marta; Wollbrett, Julien; Echchiki, Amina; Escoriza, Angelique; Gharib, Walid H.; Gonzales-Porta, Mar; Jarosz, Yohan; Laurenczy, Balazs; Moret, Philippe; Person, Emilie; Roelli, Patrick; Sanjeev, Komal; Seppey, Mathieu; Robinson-Rechavi, Marc
err分享
err收藏
The Genotype-Tissue Expression (GTEx) project基因型-组织表达 (GTEx) 项目
errNATURE GENETICS
IF31.8
err2013-05-29
err6.2K
errOAAI
errLonsdale, John; Thomas, Jeffrey; Salvatore, Mike; Phillips, Rebecca; Lo, Edmund; Shad, Saboor; Hasz, Richard; Walters, Gary; Garcia, Fernando; Young, Nancy; Foster, Barbara; Moser, Mike; Karasik, Ellen; Gillard, Bryan; Ramsey, Kimberley; Sullivan, Susan; Bridge, Jason; Magazine, Harold; Syron, John; Fleming, Johnelle; Siminoff, Laura; Traino, Heather; Mosavel, Maghboeba; Barker, Laura; Jewell, Scott; Rohrer, Dan; Maxim, Dan; Filkins, Dana; Harbach, Philip; Cortadillo, Eddie; Berghuis, Bree; Turner, Lisa; Hudson, Eric; Feenstra, Kristin; Sobin, Leslie; Robb, James; Branton, Phillip; Korzeniewski, Greg; Shive, Charles; Tabor, David; Qi, Liqun; Groch, Kevin; Nampally, Sreenath; Buia, Steve; Zimmerman, Angela; Smith, Anna; Burges, Robin; Robinson, Karna; Valentino, Kim; Bradbury, Deborah; Cosentino, Mark; Diaz-Mayoral, Norma; Kennedy, Mary; Engel, Theresa; Williams, Penelope; Erickson, Kenyon; Ardlie, Kristin; Winckler, Wendy; Getz, Gad; DeLuca, David; MacArthur, Daniel; Kellis, Manolis; Thomson, Alexander; Young, Taylor; Gelfand, Ellen; Donovan, Molly; Meng, Yan; Grant, George; Mash, Deborah; Marcus, Yvonne; Basile, Margaret; Liu, Jun; Zhu, Jun; Tu, Zhidong; Cox, Nancy J.; Nicolae, Dan L.; Gamazon, Eric R.; Im, Hae Kyung; Konkashbaev, Anuar; Pritchard, Jonathan; Stevens, Matthew; Flutre, Timothee; Wen, Xiaoquan; Dermitzakis, Emmanouil T.; Lappalainen, Tuuli; Guigo, Roderic; Monlong, Jean; Sammeth, Michael; Koller, Daphne; Battle, Alexis; Mostafavi, Sara; McCarthy, Mark; Rivas, Manual; Maller, Julian; Rusyn, Ivan; Nobel, Andrew; Wright, Fred; Shabalin, Andrey; Feolo, Mike; Sharopova, Nataliya; Sturcke, Anne; Paschal, Justin; Anderson, James M.; Wilder, Elizabeth L.; Derr, Leslie K.; Green, Eric D.; Struewing, Jeffery P.; Temple, Gary; Volpi, Simona; Boyer, Joy T.; Thomson, Elizabeth J.; Guyer, Mark S.; Cathy Ng; Abdallah, Assya; Colantuoni, Deborah; Insel, Thomas R.; Koester, Susan E.; Little, A. Roger; Bender, Patrick K.; Lehner, Thomas; Yao, Yin; Compton, Carolyn C.; Vaught, Jimmie B.; Sawyer, Sherilyn; Lockhart, Nicole C.; Demchok, Joanne; Moore, Helen F.
err分享
err收藏
GEPIA: a web server for cancer and normal gene expression profiling and interactive analysesGEPIA: 用于癌症和正常基因表达谱分析和交互式分析的网络服务器
errNUCLEIC ACIDS RESEARCH
IF13.1
err2017-04-12
err7.2K
errOAAI
errTang, Zefang; Li, Chenwei; Kang, Boxi; Gao, Ge; Li, Cheng; Zhang, Zemin
err分享
err收藏
What are housekeeping genes?
errplos biology
IF3.6
err2022-07-13
err68
errOAAI
errJoshi, Chintan J.; Ke, Wenfan; Drangowska-Way, Anna; O'Rourke, Eyleen J.; Lewis, Nathan E.
err分享
err收藏
Gene Expression Nebulas (GEN): a comprehensive data portal integrating transcriptomic profiles across multiple species at both bulk and single-cell levels
errNUCLEIC ACIDS RESEARCH
IF13.1
err2021-09-30
err22
errOAAI
errZhang, Yuansheng; Zou, Dong; Zhu, Tongtong; Xu, Tianyi; Chen, Ming; Niu, Guangyi; Zong, Wenting; Pan, Rong; Jing, Wei; Sang, Jian; Liu, Chang; Xiong, Yujia; Sun, Yubin; Zhai, Shuang; Chen, Huanxin; Zhao, Wenming; Xiao, Jingfa; Bao, Yiming; Hao, Lili; Zhang, Zhang
err分享
err收藏
Determinants of telomere length across human tissues人体组织端粒长度的决定因素
errSCIENCE
IF45.8
err2020-09-11
err301
errOAAI
errDemanelis, Kathryn; Jasmine, Farzana; Chen, Lin S.; Chernoff, Meytal; Tong, Lin; Delgado, Dayana; Zhang, Chenan; Shinkle, Justin; Sabarinathan, Mekala; Lin, Hannah; Ramirez, Eduardo; Oliva, Meritxell; Kim-Hellmuth, Sarah; Stranger, Barbara E.; Lai, Tsung-Po; Aviv, Abraham; Ardlie, Kristin G.; Aguet, Francois; Ahsan, Habibul; Doherty, Jennifer A.; Kibriya, Muhammad G.; Pierce, Brandon L.
err分享
err收藏
Do Housekeeping Genes Exist?
errPLOS ONE
IF0
err2015-05-13
err0
errOAAI
errYijuan Zhang; Ding Li; Bingyun Sun
err分享
err收藏
PaGeFinder: quantitative identification of spatiotemporal pattern genes
errBioinformatics
IF0
err2012-04-06
err0
errOAAI
errJian-Bo Pan; Shi-Chang Hu; Hao Wang; Quan Zou; Zhi-Liang Ji
err分享
err收藏
Research Progress in Alpha-fetoprotein-induced Immunosuppression of Liver Cancer甲胎蛋白诱导肝癌免疫抑制的研究进展
errMINI-REVIEWS IN MEDICINAL CHEMISTRY
IF3.3
err2022-09-01
err16
PREAI
errZhao, Kailiang; Zhou, Xiaoquan; Xiao, Yuchun; Wang, Yanni; Wen, Lu
err分享
err收藏
TEDD: a database of temporal gene expression patterns during multiple developmental periods in human and model organisms
errNUCLEIC ACIDS RESEARCH
IF13.1
err2022-11-09
err11
errOAAI
errZhou, Ziheng; Tan, Cong; Chau, Matthew Hoi Kin; Jiang, Xiaosen; Ke, Ziyuan; Chen, Xiaoyan; Cao, Ye; Kwok, Yvonne K.; Bellgard, Matthew; Leung, Tak Yeung; Choy, Kwong Wai; Dong, Zirui
err分享
err收藏
学者 查看更多内容