.png){kind=icon}
返回
Hydroxychloroquine Improves Low Complement Levels
.png){kind=icon}
OA
AI
DOI：10.1002/acr.25381.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
ObjectiveHaving a low complement level is associated with clinical systemic lupus erythematosus (SLE) disease activity and future organ damage. We studied the association of hydroxychloroquine (HCQ) whole blood levels with changes in complement level. MethodsWe performed two analyses on data prospectively collected from an SLE cohort. In the first (a new starts on HCQ analysis), we compared changes in complement level between those starting HCQ and those not starting it. The second analysis evaluated the association between HCQ whole blood levels and low complement level in all cohort visits using conditional logistic regression. ResultsIn the new starts on HCQ analysis, a higher percentage of patients starting HCQ (as reflected in HCQ blood levels >50) experienced a normalization of C4 level compared to those not starting HCQ (23 of 57 [40%] vs. 9 of 56 [13%]; P = 0.011), as well as a significantly greater increase in both C3 and C4 level (P = 0.048 and P = 0.017, respectively). In the all cohort visits analysis, there was a statistically significant higher probability of having normal C4 levels in visits with higher HCQ whole blood levels (odds ratio 1.8-2.6 depending on the levels). This relationship was most pronounced for whole blood HCQ levels of 200 ng/mL or more. ConclusionWe observed significant improvement in complement levels when HCQ was started and among those with higher whole blood levels of HCQ, particularly with respect to C4. Modulating the pathogenic mechanisms that lead to complement consumption may be one mode by which HCQ prevents poor outcomes in SLE.
Keyword:
SYSTEMIC-LUPUS-ERYTHEMATOSUS
COHORT
RISK
期刊
A
IF:
3.3
论文数:
4.3K
被引数:
1.8W
机构
引用论文
A Light-Weight Defect Classification Scheme for Embedded Automotive Software and Its Initial Evaluation一种轻量级嵌入式汽车软件缺陷分类方案及其初步评估
PREAI
分享收藏Accounting for the bad apples: the EU's impact on national corruption before and after accession
PREAI
分享收藏The Similarity between Tuftsin (Thr‐Lys‐Pro‐Arg) Receptors and Tuftsin Antibody: A Case of Induced Molecular MimicryaTuftsin (Thr‐Lys‐Pro‐Arg) 受体与 Tuftsin 抗体之间的相似性：诱导分子模拟的一个案例a
PREAI
分享收藏Association of Higher Hydroxychloroquine Blood Levels With Reduced Thrombosis Risk in Systemic Lupus Erythematosus.png)
ARTHRITIS & RHEUMATOLOGY
OAAI
ARTHRITIS & RHEUMATOLOGYIF10.9
OAAI分享收藏
查看更多内容