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Hypothalamic microstructure and function are associated with mild cognitive impairment in aging
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DOI：10.1016/j.brainresbull.2026.111921.png)
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Abstract
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• Subregional Profiling: Hypothalamic degeneration in MCI is not a uniform global process, but exhibits marked spatial heterogeneity and sexual dimorphism. • Microstructural Biomarker: Beyond macroscopic atrophy, high-resolution DTI identifies specific microstructural degradation (reduced FA) uniquely localized in the left anterior-inferior subregion of MCI patients. • Clinical Relevance: Microarchitectural disruption in the left tubular-superior subregion serves as a sensitive indicator, strongly correlating with both general cognitive decline and loss of functional independence. • Cognitive Reserve: Higher educational attainment acts as a protective factor, independently correlating with preserved microstructural integrity in the posterior hypothalamus.
Keywords:
Mild cognitive impairment
Hypothalamus
Diffusion tensor imaging
Sex dimorphism
Cognitive reserve
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