Ibrutinib enhances stem-cell-memory T cell generation during early T cell activation but inhibits T cell proliferation

Ling He

doi:10.1016/j.cellimm.2026.105065

Ibrutinib enhances stem-cell-memory T cell generation during early T cell activation but inhibits T cell proliferation

2026-02-02

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PRE

AI

L

Ling He

Y

Yifei Liu

J

Junjie Zhou

T

Taiyan Zhang

S

Shihao Zhang

J

Jian Ge

J

Jian Hong *

DOI：10.1016/j.cellimm.2026.105065

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• Ibrutinib enhanced Tscm cell generation only during the initial phase of T cell activation. • Ibrutinib suppressed the proliferation and cytokine-secretion capacity of T cells. • Ibrutinib's T-cell effects involve downregulating mTORC1 and upregulating FOXO1.

Ibrutinib enhances stem-cell-memory T cell generation during early T cell activation but inhibits T cell proliferation

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