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Identifying spatial domains from spatial multi-omics data using consistent and specific deep subspace learning

delete2025-06-27
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PRE
AI
G
Guangchang Cai
F
Fuqun Chen
K
Kepei Wen
李颖 cover
李颖 (Ying Li)
欧阳乐 cover
欧阳乐 (Le Ou-Yang)
DOI:10.1016/j.inffus.2025.103428delete
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Abstract

Abstract

En 中文
• A deep subspace learning model is proposed for spatial domain identification. • Our model captures local features and uses self-expression to learn global affinities. • The consistent and complementary cross-omics information is effectively extracted. • Dual constraints are introduced to enhance information extraction. • Experiments demonstrate that our model consistently outperforms existing methods.
Keywords:
Spatial multi-omics data
Spatial domain identification
Deep subspace clustering
Multi-view learning

Journal

Information Fusion cover
Information Fusion
IF:
15.5
Papers:
4.1K
Citations:
2.7W

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