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IgE-sensitized mast cells release extracellular vesicles that transfer IgE and spread allergic sensitization
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DOI：10.1016/j.jaci.2026.06.019.png)
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Abstract
En 中文
Elevated IgE levels are linked to allergic conditions. IgE binding to FcεRI sensitizes mast cells (MCs), and allergen-induced cross-linking of IgE-bound FcεRI triggers MC activation. Extracellular vesicles (EVs), implicated in intercellular communication, are coreleased during IgE-mediated MC degranulation. Although extensive research has examined MC activation, the effects of IgE sensitization alone on MCs remain less understood.
Keywords:
Allergic sensitization
extracellular vesicles
FcεRI
immunoglobulin E
mast cell
BMMC
Bone marrow–derived MC
DC
Dendritic cell
EV
Extracellular vesicle
FA
Food allergic
GO
Gene Ontology (geneontology.org)
huMC
Human MC
LAD2
Laboratory of Allergic Diseases 2 human MC line
MC
Mast cell
PCA
Principal component analysis
PG
Phosphatidylglycerol
PM
Plasma membrane
sEV
Small EV
SM
Sphingomyelin
XL
Cross-linking
Journal
IF:
11.2
Papers:
3.7W
Citations:
5.6W
Organization
No organization information available
Cited Papers