.png){kind=icon}
.png){kind=icon}
Return
IL-1–Activated Inflammatory Cardiac Fibroblasts Exacerbate Acute Coxsackievirus B3 Myocarditis
.png){kind=icon}
OA
AI
D
W
M
C
A
I
M
N
O
V
D
DOI：10.1016/j.jacbts.2026.101637.png)
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
• Inflammatory fibroblasts drive viral myocarditis and represent a therapeutic target. • IL-1 induces inflammatory fibroblasts that amplify cardiac immune responses. • Blocking fibroblast IL-1 signaling reduces myocarditis while preserving immunity. • Future work should target inflammatory fibroblasts to improve myocarditis treatment.
Keywords:
IL-1
inflammatory fibroblasts
plasticity
viral myocarditis
CF
cardiac fibroblast
CVB3
Coxsackievirus B3
EAM
experimental autoimmune myocarditis
ECM
extracellular matrix
FACS
fluorescence-activated cell sorting
GM-CSF
granulocyte-macrophage colony-stimulating factor
H&E
hematoxylin and eosin
IF
inflammatory fibroblast
LPS
lipopolysaccharide
qPCR
quantitative polymerase chain reaction
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
IF:
7.2
Papers:
1.2K
Citations:
4.3K
Organization
Cited Papers