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IL-1 confers IgG-mediated protection against allergic anaphylaxis
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DOI：10.1016/j.jaci.2026.07.011.png)
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Abstract
En 中文
• IL-1 promotes allergen-specific IgG responses that reduce allergic anaphylaxis through FcγRIIb-dependent mechanisms. • Recombinant IL-1β administration with allergen reduces systemic and food allergy responses in preventive and therapeutic settings. • IL-1β up-regulates FcγRIIb in mast cells, to rapidly lower sensitivity to allergen
Keywords:
Interleukin-1
Allergen immunotherapy (AIT
SIT)
IgE
allergy
Adjuvant
antibodies
FcγRIIb
mast cells
basophils
Immune Deviation
AIT
Allergen immunotherapy
BMMC
Bone marrow-derived mast cell
GC
Germinal center
IC
Immune complex
i.p.
Intraperitoneal
IL-1
Interleukin-1
IL-1β
Interleukin-1 beta
IL-1Ra
Interleukin-1 receptor antagonist
i.v.
Intravenous
OD
Optical density
OD50
Half-maximal optical density titer
OVA
Ovalbumin
PBS
Phosphate-buffered saline
PBS-T
Phosphate-buffered saline with Tween-20
PBMC
Peripheral blood mononuclear cells
PCA
Principal component analysis
PMC
Peritoneal mast cell
p.o.
per os (oral gavage)
RBC
Red blood cell
RRID
Research Resource Identifier
s.c.
Subcutaneous
SCF
Stem cell factor
SEM
Standard error of the mean
Tfh
T follicular helper cell
Tfr
T follicular regulatory cell
WT
Wild-type
FcεRI
High-affinity IgE receptor
FcγRIIb
Fc gamma receptor IIb
FCS
Fetal calf serum
Journal
IF:
11.2
Papers:
3.7W
Citations:
5.6W
Organization
Cited Papers