.png){kind=icon}
.png){kind=icon}
Return
IL-31: A new key player in dermatology and beyond
.png){kind=icon}
OA
AI
I
T
DOI：10.1016/j.jaci.2017.10.045.png)
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
IL-31 is a novel cytokine expressed in many human tissues and involved mainly in T(H)2-weighted inflammation. IL-31 signals through a receptor complex consisting of IL-31 receptor a and oncostatin M receptor b. The available data show that IL-31 is strongly linked with chronic pruritic skin disorders, such as atopic eczema, and represents a novel target for directed drug therapy. Regulation of immune responses and cellular differentiation and proliferation are recently elucidated effects of IL-31, suggesting a more complex and diverse area of effect for this novel cytokine. This review summarizes the current knowledge on IL-31 and its receptors and the involvement of IL-31 in diseases both in human subjects and mouse models.
Keywords:
IL-31
receptors
interleukins
cytokines
pruritus
atopic eczema
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
IF:
11.2
Papers:
3.7W
Citations:
5.6W
Organization
Cited Papers