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Imaging Neoangiogenesis in Rheumatoid Arthritis (INIRA) Part II: Whole-body Synovial Uptake of 99 mTc-maraciclatide is Highly Correlated with Power Doppler Ultrasound

delete2025-08-05
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PRE
AI
L
Laura Attipoe *
S
Sujith Subesinghe
C
Cristina Blanco-Gil
M
Maria Opena
S
Sam Norton
M
Mark Rosser
A
Andrew P. Cope
G
Gary Cook
T
Toby Garrood
DOI：10.1016/j.acra.2025.06.013delete
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Abstract

Abstract

En 中文
Ultrasound (US) and MRI are more sensitive than clinical examination in detecting synovitis in patients with rheumatoid arthritis (RA). It is impractical however to image large numbers of joints in routine settings. 99 mTc-maraciclatide is a radio-labeled small molecule tracer which binds with high affinity to integrin αvβ3, a cell-adhesion molecule up-regulated on neoangiogenic blood vessels, and therefore has the potential to image synovial inflammation at the whole-body level. This study explores whether 99 mTc-maraciclatide joint uptake correlates and agrees with power Doppler ultrasound (PDUS) in patients with RA.
Keywords:
ultrasound
MRI
synovitis
rheumatoid arthritis
99mTc-maraciclatide
integrin αvβ3
power Doppler ultrasound

Journal

Academic Radiology cover
Academic Radiology
IF:
3.9
Papers:
8.6K
Citations:
1.0W

Organization

S
serac life sciences, 6th floor charlotte building, 17 gresse street
Scholars:
1
Papers: 1
Citations: 0
D
Department of Rheumatology
Scholars:
992
Papers: 401
Citations: 1
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