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Immunosensor with self-referencing based on surface plasmon diffraction

delete2004-03-09
delete52
PRE
AI
F
Fang Yu
W
Wolfgang Knoll
DOI:10.1021/ac035369wdelete
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摘要

摘要

En 中文
We propose a novel type of immunosensor based on the diffraction of surface plasmon, which allows for in situ, real-time, and label-free observation of interfacial binding events. The inherent self-referencing mechanism of surface diffraction was found to be very effective for compensating fluctuations of the bulk, demonstrated by a temperature variation experiment. Possessing a stable baseline signal, the diffraction sensor offered picomolar sensitivity in directly detecting the binding of human chorionic gonadotropin (hCG) hormone.
Keyword:
CELL
RECOGNITION
BIOSENSOR
ANTIBODY
ASSAY
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期刊

Analytical Chemistry 封面图
Analytical Chemistry
IF:
6.7
论文数:
4.7W
被引数:
15.9W

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