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Impact of chronic REM sleep deprivation on glucose homeostasis, insulin sensitivity, oxidative stress, and histological changes in adult male Wistar rats
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DOI：10.1016/j.sleep.2026.109105.png)
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Abstract
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• Chronic REM-SD alters glucose metabolism and increases insulin resistance. • Chronic REM-SD induces hyperglycemia and disrupts the lipid profile. • Chronic REM-SD alters liver and kidney function and induces tissue lysis. • Chronic REM-SD induces oxidative stress with an increase in ROS and a decrease in CAT and SOD activity. • Chronic REM-SD induces a decrease in BuChE and an increase in serum CORT.
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