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Impact of silk-derived sericin on the formation and metformin sensitivity of breast cancer-fibroblast heterotypic spheroids
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DOI：10.1016/j.bioadv.2026.215022.png)
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Abstract
En 中文
• Sericin contributes to the formation of heterotypic 3D breast tumor spheroid formation. • Low share stress under orbital agitation supports stable and reproducible spheroid assembly. • The supplementation of 0.1% sericin has been demonstrated to enhance the compactness, sphericity, and integrity of spheroids. • Sericin-based 3D models enhance physiological relevance for drug testing and cancer research.
Keywords:
Sericin
Spheroid formation
3D models
Tumor microenvironment
Metformin
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