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Implementing Logic Gates by DNA Crystal Engineering
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DOI：10.1002/adma.202302345.png)
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摘要
En 中文
DNA self-assembly computation is attractive for its potential to perform massively parallel information processing at the molecular level while at the same time maintaining its natural biocompatibility. It has been extensively studied at the individual molecule level, but not as much as ensembles in 3D. Here, the feasibility of implementing logic gates, the basic computation operations, in large ensembles: macroscopic, engineered 3D DNA crystals is demonstrated. The building blocks are the recently developed DNA double crossover-like (DXL) motifs. They can associate with each other via sticky-end cohesion. Common logic gates are realized by encoding the inputs within the sticky ends of the motifs. The outputs are demonstrated through the formation of macroscopic crystals that can be easily observed. This study points to a new direction of construction of complex 3D crystal architectures and DNA-based biosensors with easy readouts.
Keyword:
DNA nanotechnology
DNA nanostructures
DNA computing
DNA crystal engineering
logic gates
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期刊
IF:
26.8
论文数:
3.4W
被引数:
46.0W
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引用论文
Propelling DNA Computing with Materials' Power: Recent Advancements in Innovative DNA Logic Computing Systems and Smart Bio-Applications.png)
ADVANCED SCIENCEOAAI
ADVANCED SCIENCEIF14.1
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