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Improving Process Understanding in Roll Compaction
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DOI：10.1016/j.xphs.2021.09.024.png)
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Abstract
En 中文
Roll compaction/ dry granulation is gaining importance. Numerous papers have been published and many attempts to model the process are available in the meantime. Johanson published a model in 1965, which is the basis for many further modifications until today. The aim of the paper is to improve process understanding in roll compaction, which can be used to setup a roll compaction process, to design a scale-up strategy or to help in process transfer between different types of roll compactors. Based on some assumptions, simple considerations help to estimate a required densification factor and to visualize the relations between roll diameter, gap width and nip angle. Two recently published papers based on simplified Johansen models are used to visualize the relations between specific compaction force and the maximal pressure experienced by the material. The influence of roll diameter, gap width and compressibility constant are discussed. This helps to estimate, if a scale-up or process transfer is reasonable. The recently introduced dimensionless Midouxnumber can also be used to design scale-up or process transfer of roll compaction without knowledge about the maximal pressure. Exploring the simple concepts can help to improve process understanding even without a background in engineering. (c) 2021 The Authors. Published by Elsevier Inc. on behalf of American Pharmacists Association. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Keywords:
Roll compaction
Process understanding
Scale-up
Process transfer
Process control
Solid fraction
Densification factor
Journal
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3.8
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1.1W
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2.6W