.png){kind=icon}
返回
Incomplete Cell Sorting Creates Engineerable Structures with Long-Term Stability
.png){kind=icon}
OA
AI
DOI：10.1016/j.xcrp.2020.100305.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Adhesion-mediated cell sorting has long been considered an organizing principle in developmental biology. While most computational models have emphasized the dynamics of segregation to fully sorted structures, cell sorting can also generate a plethora of transient, incompletely sorted states. The timescale of such states in experimental systems is unclear: if they are long-lived, they can be harnessed by development or engineered in synthetic tissues. Here, we use experiments and computational modeling to demonstrate how such structures can be systematically designed by quantitative control of cell composition. By varying the number of highly adhesive and less adhesive cells in multicellular aggregates, we find the cell-type ratio and total cell count control pattern formation, with resulting structures maintained for several days, Our work takes a step toward mapping the design space of self-assembling structures in development and provides guidance to the emerging field of shape engineering with synthetic biology.
Keyword:
SELF-ORGANIZATION
ADHESION
PLATFORM
TISSUES
期刊
IF:
7.3
论文数:
2.8K
被引数:
1.2W
机构
引用论文
.png){kind=icon}
Coaction of intercellular adhesion and cortical tension specifies tissue surface tension细胞间粘附和皮质张力的共同作用指定了组织表面张力
OAAI
OAAI分享收藏分享收藏
查看更多内容