“Infection Prevention Strategies for Carbapenem-Resistant and ESBL-Producing Gram-Negative Bacteria in Intensive Care Units: A Systematic Review with Exploratory Component Network Meta-analysis”

Alejandra Guarnizo-Lozano

doi:10.1016/j.ajic.2026.06.030

“Infection Prevention Strategies for Carbapenem-Resistant and ESBL-Producing Gram-Negative Bacteria in Intensive Care Units: A Systematic Review with Exploratory Component Network Meta-analysis”

2026-07-07

0

OA

AI

A

Alejandra Guarnizo-Lozano

D

Daniela Saa González

C

Cándida Díaz-Brochero *

L

Laura Cristina Nocua-Báez

J

Javier Mora Arteaga

Ó

Óscar Orlando Sanabria Rodríguez

S

Sandra Valderrama-Beltrán

DOI：10.1016/j.ajic.2026.06.030

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Abstract

En 中文

• Multimodal IPC bundles reduced MDR Gram-negative acquisition in ICUs. • No individual IPC component showed a significant independent effect. • Component network meta-analysis identified promising IPC combinations. • Evidence certainty was low because of heterogeneity and indirect evidence. • Comparative trials are needed to optimize ICU infection prevention.

Keywords:

Carbapenem-resistant Gram-negative bacilli

Extended-spectrum betalactamase–producing Enterobacterales

Infection prevention and control

Intensive care units

Network meta-analysis

“Infection Prevention Strategies for Carbapenem-Resistant and ESBL-Producing Gram-Negative Bacteria in Intensive Care Units: A Systematic Review with Exploratory Component Network Meta-analysis”

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