Inflammation in multiple system atrophy

Marta Leńska‐Mieciek

doi:10.3389/fimmu.2023.1214677

2023-06-22

Marta Leńska‐Mieciek *

Natalia Madetko‐Alster

DOI：10.3389/fimmu.2023.1214677

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摘要

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Misfolding protein aggregation inside or outside cells is the major pathological hallmark of several neurodegenerative diseases. Among proteinopathies are neurodegenerative diseases with atypical Parkinsonism and an accumulation of insoluble fibrillary alpha-synuclein (synucleinopathies) or hyperphosphorylated tau protein fragments (tauopathies). As there are no therapies available to slow or halt the progression of these disea ses, targeting the inflammatory process is a promising approach. The inflammatory biomarkers could also help in the differential diagnosis of Parkinsonian syndromes. Here, we review inflammation's role in multiple systems atrophy pathogenesis, diagnosis, and treatment.

Keyword:

multiple system atrophy (MSA)

neurodegeneration

inflammation

synucleinopathies

tauopathies

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期刊

Frontiers in Immunology

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5.9

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5.1W

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22.7W

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Medical University of Warsaw

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9.6K

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centre of postgraduate medical education - poland

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1.8K

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