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Integrated in vivo and in silico validation of Corchorus olitorius seed-mediated cardioprotection against doxorubicin-induced cardiotoxicity via network pharmacology; molecular docking; and molecular dynamics
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DOI：10.3389/fchem.2026.1810825.png)
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Abstract
En 中文
BackgroundCorchorus olitorius L.; known in Arab countries as molokhia; is a leafy plant rich in many carotenoids; minerals; and vitamins; its seeds are also reported to offer cardioprotective effects. Although the cardioprotective effects of molokhia are ascribed to the presence of cardiac glycoside compounds; the exact action mechanisms remain uninvestigated.MethodsIn this study; we examined the potential of molokhia seeds to protect against cardiopathy by isolating the major constituents of C. olitorius seeds; analyzing its gene expression in vivo; and conducting computational studies to demonstrate the cardioprotective activities of these constituents.ResultsCrude extracts of C. olitorius seeds were found to reduce the expression of IL-1β; IL-6; TNF-α; NF-κB; ICAM-1; and MMP-9 that had increased upon the administration of doxorubicin (DOX). Electrocardiographic studies showed reduced heart rate along with prolongation of the PR interval; QRS complex; and ST segment upon Corchorus administration.ConclusionThe findings of this study demonstrate that the cardioprotective effects of molokhia seeds against DOX-induced cardiotoxicity are probably mediated via anti-inflammatory actions.
Keywords:
molecular docking
network pharmacology
NF-κB
AKT1
cardioprotection
doxorubicin-induced cardiotoxicity
cardiac glycosides
Corchorus olitorius
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