.png){kind=icon}
.png){kind=icon}
Return
Integrated single-cell multi-omics analysis identifies fibroblast-like smooth muscle cells as a key driving phenotypic switching during aortic aneurysm progression
.png){kind=icon}
PRE
AI
J
W
DOI：10.1016/j.yjmcc.2026.05.006.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
• Single-cell multi-omics reveals distinct smooth muscle cell heterogeneity in human aortic aneurysm. • Fibroblast-like SMCs expand during aneurysm progression and act as a progenitor-like population. • Fibroblast-like SMCs exhibit enhanced glycolysis and increased histone lactylation. • KAT5 links metabolic reprogramming to SMC stemness via the Wnt/KLF4 pathway. • A metabolism–epigenetic axis drives smooth muscle cell phenotypic switching in aneurysm progression.
Keywords:
smooth muscle cells
single-cell multi-omics
phenotypic switching
aortic aneurysm
metabolic reprogramming
Journal
IF:
4.7
Papers:
9.9K
Citations:
1.4W
Organization
Cited Papers