Intense Incidental F-18 DOPA Uptake in Low-grade Prostate Adenocarcinoma: A Potential Diagnostic Pitfall

Mas Pascasio, Carlos MD

doi:10.1097/RLU.0000000000006596

Intense Incidental F-18 DOPA Uptake in Low-grade Prostate Adenocarcinoma: A Potential Diagnostic Pitfall

2026-06-30

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Mas Pascasio, Carlos MD

R

Ruíz de Almirón de Andrés, Blanca MD

L

López Rodríguez, Estefanía MD

S

Sanz Viedma, Salomé MD, PhD

DOI：10.1097/RLU.0000000000006596

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F-18 DOPA PET/CT is well established in the evaluation of neuroendocrine tumors and pheochromocytoma/paraganglioma. Prostatic uptake is not part of its usual physiological biodistribution, and its significance in conventional prostate adenocarcinoma remains unclear. We report intense incidental prostatic F-18 DOPA uptake in a 60-year-old man undergoing evaluation for persistently elevated normetanephrines. PET/CT showed 2 highly avid foci in the posterior-inferior prostate. Multiparametric MRI was not suspicious, but biopsy revealed acinar adenocarcinoma, Gleason score 3+3, ISUP grade 1, without neuroendocrine marker expression. This finding represents a potential diagnostic pitfall and supports cautious interpretation of focal pelvic F-18 DOPA uptake.

Keywords:

F-18 DOPA PET/CT

prostate adenocarcinoma

incidental uptake

diagnostic pitfall

nuclear medicine

Intense Incidental F-18 DOPA Uptake in Low-grade Prostate Adenocarcinoma: A Potential Diagnostic Pitfall

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