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摘要
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A long-term goal of the field of interactome modeling is to understand how global and local properties of complex macromolecular networks impact on observable biological properties, and how changes in such properties can lead to human diseases. The information available at this stage of development of the field provides strong evidence for the existence of such interesting global and local properties, but also demonstrates that many more datasets will be needed to provide accurate models with increasingly predictive capacity. This review focuses on an early attempt at mapping a multicellular interactome network and on the lessons learned from that attempt. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Keyword:
ORFeome
interactome
network biology
systems
biology
integrative omics
reverse two-hybrid system
interaction-defective alleles
期刊
IF:
3
论文数:
2.3W
被引数:
3.8W
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