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Interleukin-6 and interferon-alpha differentially regulate microglia function
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DOI：10.1111/nan.13003.png)
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Previous reports have shown that IL-6 and IFN-alpha induce distinct transcriptomic and morphological changes in microglia. Here, we demonstrate that IL-6 increases tissue surveillance, migration and phagocytosis in primary murine microglia, whereas IFN-alpha inhibits these functions. Our results provide a crucial link between transcriptome and function. It holds the potential to serve as the foundation for future studies aimed at identifying therapeutic targets for cytokine-mediated neuroinflammatory diseases.
Keyword:
interferon-alpha
interleukin-6
microglia
migration
phagocytosis
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