.png){kind=icon}
.png){kind=icon}
Return
Intermittent cocaine use patterns, not total intake, predict cue-induced drug seeking in rats
.png){kind=icon}
OA
AI
DOI：10.1111/bph.70596.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Cocaine-associated cues trigger relapse to drug use in humans and animal models. In rats, long daily cocaine access (4–6 vs. 1–2 h) increases drug self-administration and cue-induced cocaine seeking, suggesting that greater intake promotes relapse. However, prior studies used continuous drug access paradigms, whereas human cocaine use is typically intermittent. Prior studies also used conditioned stimuli (CS), whereas discriminative stimuli (DS) are more effective in triggering drug seeking. Here, we used intermittent access (IntA) self-administration to examine how session length influences CS- and DS-induced cocaine seeking.
Keywords:
addiction
conditioned stimulus
discriminative stimulus
intermittent access
Long-Access
Short-Access
relapse
risk factor
Journal
IF:
7.7
Papers:
1.4W
Citations:
3.7W