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Intranasal mucoadhesive chitosan microspheres of ranolazine: Formulation, design, and pharmacokinetic evaluation
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DOI：10.1016/j.xphs.2026.104399.png)
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Abstract
En 中文
• Chitosan microspheres were developed for intranasal delivery of ranolazine. • The formulation exhibited strong mucoadhesion and sustained drug release. • Histopathology confirmed nasal mucosa safety of the microspheres. • In vivo studies showed improved bioavailability over conventional delivery. • A novel nasal platform was demonstrated for poorly soluble anti-anginal drugs.
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