Ionic-Liquid-Based Safe Adjuvants

Anvay Ukidve

doi:10.1002/adma.202002990

2020-10-15

DOI：10.1002/adma.202002990

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摘要

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Adjuvants play a critical role in the design and development of novel vaccines. Despite extensive research, only a handful of vaccine adjuvants have been approved for human use. Currently used adjuvants are mostly composed of components that are non-native to the human body, such as aluminum salt, bacterial lipids, or foreign genomic material. Here, a new ionic-liquid-based adjuvant is explored, synthesized using two metabolites of the body, choline and lactic acid (ChoLa). ChoLa distributes the antigen efficiently upon injection, maintains antigen integrity, enhances immune infiltration at the injection site, and leads to a potent immune response against the antigen. Thus, it can serve as a promising safe adjuvant platform that can help to protect against pandemics and future infectious threats.

Keyword:

adjuvants

choline

immune modulation

ionic liquids

lactic acid

vaccines

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Advanced Materials

IF:

26.8

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3.5W

被引数:

46.0W

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university of michigan system

学者数:

593

论文数: 1.5K

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Harvard University

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5.7K

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