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Iron overload inhibits neuronal extracellular vesicles secretion via SNARE dysfunction

delete2026-05-26
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PRE
AI
X
Xiaoting Wang
Y
Yang Li
X
Xiaoqing Mi
T
Tongtong Yang
Y
Yun Li
J
Jinjie Zhang
F
Fengju Jia *
J
Junxia Xie *
N
Ning Song *
DOI：10.1016/j.neuint.2026.106192delete
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Abstract

Abstract

En 中文
• Brain iron deposition reduces neuron-derived extracellular vesicles secretion in vivo. • Iron overload inhibits exosome release in PC12 cells in vitro. • SNARE complex dysfunction mediate iron-induced exosome inhibition. • Neuron-derived extracellular vesicles increase in plasma during ageing.
Keywords:
Iron overload
Neuronal extracellular vesicles
SNARE complex
Exosome secretion
Aging

Journal

Neurochemistry International cover
Neurochemistry International
IF:
4
Papers:
5.3K
Citations:
1.0W

Organization

P
peking university
Scholars:
11.5W
Papers: 8.6W
Citations: 146
Q
qingdao university
Scholars:
5.0K
Papers: 1.5K
Citations: 0
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