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Lactate fermentation intoxicates TILs
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DOI：10.1038/s41590-024-02020-7.png)
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Tumor-infiltrating T cells are known to encounter chronic antigens and hypoxia, which results in exhaustion and dysfunction. New data show that lactate fermentation, a characteristic of solid tumors, promotes the uptake of lactate into T cells via the monocarboxylate transporter MCT11, which reduces the metabolic fitness and anti-tumor function of these cells, an effect that might be targeted by immunotherapy.
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分享收藏Mitochondrial metabolic flexibility is critical for CD8+ T cell antitumor immunity.png)
SCIENCE ADVANCES
OAAI
SCIENCE ADVANCESIF12.5
OAAI分享收藏Histone lactylation drives CD8+ T cell metabolism and function组蛋白乳糖化驱动CD8 T细胞代谢和功能NATURE IMMUNOLOGY
NATURE IMMUNOLOGYIF27.6
PREAI
分享收藏Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade耗竭的CD8 T细胞亚群差异介导肿瘤控制并响应检查点阻断NATURE IMMUNOLOGYOAAI
NATURE IMMUNOLOGYIF27.6
OAAI分享收藏Dysfunction of exhausted T cells is enforced by MCT11-mediated lactate metabolism乳酸代谢MCT11-mediated增强了疲惫的T细胞功能障碍NATURE IMMUNOLOGYOAAI
NATURE IMMUNOLOGYIF27.6
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