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Lactate promotes liver regeneration by increasing fatty acid oxidation through GCN5-mediated H3K9 lactylation
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DOI：10.1016/j.jcmgh.2026.101859.png)
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Abstract
En 中文
Lactylation has been implicated in the repair and regeneration of multiple organs including skin and heart. The liver serves as a vital organ for lactate metabolism, while the roles of lactate and lactylation during liver regeneration remain unclear.
Keywords:
Liver regeneration
Histone lactylation
GCN5
Epigenetics
Fatty acid metabolism
APAP
Acetaminophen
FAO
Fatty Acid Oxidation
GO
Gene Ontology
HCC
Hepatocellular Carcinoma
HEK293T
Human Embryonic Kidney 293T
hPTMs
Histone Post-translational Modifications
H3K9la
H3K9 Lactylation
KEGG
Kyoto Encyclopedia of Genes and Genomes
Lactyl-CoA
Lactyl-coenzyme A
LW/BW
Liver-to-body Weight
NALA
Sodium Lactate
PA
Phosphatidic Acid
PHx
Partial Hepatectomy
WT
Wild-type
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