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Lactiplantibacillus plantarum ZP-6 mitigates polystyrene nanoplastics-induced liver damage in colitis mice via the gut-liver axis
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DOI：10.3389/fmicb.2025.1626941.png)
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Abstract
En 中文
IntroductionNanoplastics (NPs) have become a ubiquitous environmental pollutant that exhibits a tendency to accumulate in large quantities in the tissues of the host body (enteritis patients) with intestinal damage and poses a serious health risk; for which there is currently no suitable method for in vivo clearance. Studies have found that lactic acid bacteria has the potential to eliminate pollutants from the body.MethodsIn this study; we investigated the capacity of Lactiplantibacillus plantarum ZP-6; a strain isolated from human feces with demonstrated in vitro microplastic-binding activity; to alleviate the physiological toxicity of polystyrene nanoplastics (PS-NPs) in healthy and colitic murine models. Then; we investigated the capacity of Lactiplantibacillus plantarum ZP-6 to alleviate the physiological toxicity of polystyrene nanoplastics (PS-NPs) in healthy and colitic murine models.ResultsOur findings revealed that PS-NPs exposure resulted in systemic accumulation; triggering organ pathology and inflammatory responses in the liver and colon. Dietary intervention with Lactiplantibacillus plantarum ZP-6 significantly reduced PS-NPs retention in blood and tissues while enhancing fecal excretion; restoring hepatic; renal; and colonic histopathology to baseline levels. Mechanistically; ZP-6 downregulated pro-inflammatory cytokines (IL-1β; IL-6; TNF-α) and anti-inflammatory IL-10 in affected tissues. Gut colonization dynamics demonstrated transient enrichment of ZP-6; which facilitated PS-NPs adsorption and fecal clearance. Concurrently; ZP-6 upregulated mucin gene Muc2 and tight junction components (OCLN; CLDN1); reinforcing the intestinal epithelial barrier and impeding PS-NPs translocation. Metabolomic analysis further indicated that ZP-6 rectified PS-NPs-induced hepatic metabolic dysregulation via the gut-liver axis.ConclusionThese results elucidate a multifaceted probiotic mechanism for NPs detoxification; providing a promising translational strategy to counteract nanoplastic-related health hazards.
Keywords:
nanoplastics
Lactiplantibacillus plantarum ZP-6
gut-liver axis
intestinal barrier
inflammatory cytokines
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