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Lambda-cyhalothrin delays pubertal Leydig cell development in rats
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DOI：10.1016/j.envpol.2018.07.033.png)
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Lambda-cyhalothrin (LCT) is a widely used broad-spectrum pyrethroid insecticide and is expected to cause deleterious effects on the male reproductive system. However, the effects of LCT on Leydig cell development during puberty are unclear. The current study addressed these effects. Twenty-eight-day old male Sprague Dawley rats orally received LCT (0, 0.25, 0.5 or 1 mg/kg body weight/day) for 30 days. The levels of serum testosterone, luteinizing hormone, and follicle-stimulating hormone, Leydig cell number, and its specific gene and protein expression were determined. LCT exposure lowered serum testosterone levels at doses of 0.5 and 1 mg/kg and luteinizing hormone levels at a dose of 1 mg/kg, but increased follicle-stimulating hormone levels at doses of 0.5 and 1 mg/kg. LCT lowered Star and Hsd3b1 mRNA or their protein levels at a dose of 1 mg/kg. Immature Leydig cells were purified from pubertal rats and treated with different concentrations of LCT for 24 h and medium androgen levels, Leydig cell mRNA and protein levels, the mitochondrial membrane potential (Delta psi m), and the apoptotic rate of immature Leydig cells were investigated. LCT inhibited androgen production at 5 mu M and downregulated Scarbl at 0.05 mu M, Hsd3b1 and Hsd11b1 at 0.5 mu M, and Cyp11a1 at 5 mu M. LCT also decreased Delta psi m at 0.5 and 50 mu M. In conclusion, LCT can influence the function of Leydig cells. (C) 2018 Elsevier Ltd. All rights reserved.
Keyword:
Leydig cells
Lambda-cyhalothrin
Development
Rat
Mitochondrial membrane potential
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