.png){kind=icon}
返回
Laplace Approximated EM Microarray Analysis: An Empirical Bayes Approach for Comparative Microarray Experiments
.png){kind=icon}
OA
AI
DOI：10.1214/10-STS339.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
A two-groups mixed-effects model for the comparison of (normalized) microarray data from two treatment groups is considered. Most competing parametric methods that have appeared in the literature are obtained as special cases or by minor modification of the proposed model. Approximate maximum likelihood fitting is accomplished via a fast and scalable algorithm, which we call LEMMA (Laplace approximated EM Microarray Analysis). The posterior odds of treatment x gene interactions, derived from the model, involve shrinkage estimates of both the interactions and of the gene specific error variances. Genes are classified as being associated with treatment based on the posterior odds and the local false discovery rate (f.d.r.) with a fixed cutoff. Our model-based approach also allows one to declare the non-null status of a gene by controlling the false discovery rate (FDR). It is shown in a detailed simulation study that the approach outperforms well-known competitors. We also apply the proposed methodology to two previously analyzed microarray examples. Extensions of the proposed method to paired treatments and multiple treatments are also discussed.
Keyword:
EM algorithm
empirical Bayes
Laplace approximation
LEMMA
LIMMA
linear mixed models
local false discovery rate
microarray analysis
mixture model
two-groups model
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
3.4
论文数:
1.0K
被引数:
8.7K
机构
引用论文
Microarray expression profiling identifies genes with altered expression in HDL-deficient mice.png)
GENOME RESEARCH
OAAI
GENOME RESEARCHIF5.5
OAAI分享收藏A multivariate empirical Bayes statistic for replicated microarray time course data复制的微阵列时间过程数据的多元经验贝叶斯统计量ANNALS OF STATISTICSOAAI
ANNALS OF STATISTICSIF3.7
OAAI分享收藏Significance analysis of microarrays applied to the ionizing radiation response微阵列应用于电离辐射响应的意义分析OAAI
OAAI分享收藏Effects of phenethyl isothiocyanate on metabolism and on genotoxicity of dimethylnitrosamine and 2-amino-1-methyl-6-phenylimidazo[4, 5−b]pyridine (PhIP)异硫氰酸苯乙酯对二甲基亚硝胺和2-氨基-1-甲基-6-苯基咪唑并 [4，5-b] 吡啶 (PhIP) 的代谢和遗传毒性的影响
PREAI
分享收藏
查看更多内容